Sikuli is a visual technology to search and automate graphical user interfaces (GUI) using images (screenshots). The first release of Sikuli contains Sikuli Script, a visual scripting API for Jython, and Sikuli IDE, an integrated development environment for writing visual scripts with screenshots easily. Sikuli Script automates anything you see on the screen without internal API’s support. You can programmatically control a web page, a desktop application running on Windows/Linux/Mac OS X, or even an iphone application running in an emulator.

This looks pretty slick.